named programs · 5 · from sources
What they call their work
CDISC Datasets
Converts clinical databases into SDTM and ADaM compliant datasets to support regulatory submissions.
Data Sharing and Dissemination
Develops interactive data dashboards and prepares datasets for public repositories like NIH to support data sharing and publication.
Independent Statistical Center (ISC)
Provides independent statistical support to Data Safety Monitoring Boards and Independent Data Monitoring Committees, including customized graphical reporting for interim analyses.
Regulatory Support
Prepares statistical components of regulatory submissions for agencies such as the FDA, ensuring compliance with regulatory standards.
Statistical Analysis Plan (SAP) Development
Develops detailed statistical analysis plans specifying methodologies, analysis populations, and output layouts for clinical studies.
activities · 5 groups
What they do
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Biomedical Research and Innovation 1 activity
- Conducts clinical trials and research studiesDesigns, implements, and supports clinical trials across all phases (I-IV) in multiple therapeutic areas including HIV, cancer, cardiovascular disease, and tuberculosis, collaborating with investigators, sponsors, and research networks globally. The organization has conducted or supported over 1,200 studies in the past five decades.
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Medical Professional Education & Training 1 activity
- Delivers training and technical assistance for clinical research teamsCreates customized instructional programs, training tools, user manuals, and help guides; delivers training on data collection, case report forms, data management systems, and procedural updates; and supports onboarding and knowledge retention for clinical trial collaborators across global research sites.
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Healthcare Compliance and Ethics Programs 1 activity
- Implements quality management systems for clinical researchDevelops and implements integrated quality management systems to ensure compliance with domestic and international regulations, including conducting gap analyses, drafting standard operating procedures, managing risk, audit preparation, vendor oversight, computer system validation, and CAPA management throughout the study lifecycle.
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Data & Technology Capacity Building 1 activity
- Manages data systems and digital infrastructure for research networksDesigns, builds, hosts, and maintains secure data management platforms, study-specific websites, specimen repositories, and interactive dashboards for major research networks such as ACTG, IMPAACT, PHACS, and CP-CTNet. Develops custom software solutions including Stars (enrollment/randomization) and LDMS (laboratory specimen tracking) used globally by research sites.
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Uncategorized 2 activities
- Provides biostatistical and data management servicesOffers comprehensive biostatistical support including study design, statistical analysis, CDISC-compliant dataset creation (SDTM, ADaM), and support for regulatory submissions and peer-reviewed publications. Services span observational studies and clinical trials globally and include support for Independent Data Monitoring Committees and Data Safety Monitoring Boards.
- Provides end-to-end clinical trial data operations and monitoringManages full-cycle clinical trial data operations including database design using EDC systems (e.g., REDCap, Medidata), secure data collection, randomization, real-time reporting, data integration/harmonization, database lock, and study close-out. Conducts remote and on-site monitoring and auditing to ensure protocol adherence, participant safety, and data integrity across more than 800 global sites.
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financials · form 990 · fy2024
revenue
Total revenue$30.26M
Contributions & grants$25.05M83%
Program service revenue$5.07M17%
Investment income$146K0%
Other revenue$0
expenses
Total expenses$31.37M
Program expenses74%
Admin / overhead26%
Fundraising0%
Salaries & benefits$25.22M
Grants paid out$0
Largest expense lineCompensation
balance sheet
Total assets$19.61M
Cash$4.39M
Investments$3.05M
Liabilities$7.88M
Net assets$11.73M
Liquid reserves2.9 mo
6 years on record · 2019–2024 · YoY revenue -2.4%
leadership · form 990 part vii · fy2024
Who runs it
paid leadership · 12
| Name | Title | Hours/wk | Compensation |
|---|---|---|---|
| Suzanne Siminski | President & CEO | 40 | $456K |
| Soyeon Kim | Principal Research Scientist | 40 | $250K |
| Adel Ahmed | Chief Technology Officer | 40 | $250K |
| Lisa Zdarsky | Chief Operating Officer | 40 | $230K |
| Marlene Cooper | DMC Director for ACTG & IMPAACT | 40 | $229K |
| Piotr Meszynski | Past IT Director | 40 | $229K |
| Jamie Hoel | Director of Madison Office | 40 | $220K |
| Carol Pulver | Director of Project Operations | 40 | $216K |
| Diana Sabra | Chief Financial Officer | 40 | $194K |
| Darren Gibson | Board Member, Dir. of FSS | 0 | $178K |
| David DeMets | Board Member, Statistical Consultant | 8 | $50K |
| Richard Gelber PhD | Sr. Statistician | 4 | $39K |
board members · 9
- Carla Falkson — Board Member
- David Lagakos — Treasurer
- Frank Rockhold ScM PhD — Board Chair
- Gregory Pavlov — Past Treasurer
- Matthew Mues — Board Member
- Nuala McGrath BSc MSc ScD — Board Member
- Scott Evans PhD — Secretary
- Urania Dafni ScD — Board Member, Dir. FSF-H
- Vangelis Karkaletsis — Board Member
relationships · 34
Who they work with
- 'CASCADE' Partner — Partners with 'CASCADE' on pragmatic clinical trials to improve cervical cancer screening and treatment for women living with HIV.
- ACTG Partner — Collaborates with ACTG, a global clinical trials network for HIV/AIDS research.
- AIDS Clinical Trials Group Partner — Collaborates with Frontier Science for data management, analysis, and coordination between study teams and clinical sites.
- Academic Investigators Partner — Works with academic investigators to design and analyze research studies.
- CPQA Partner — Supports CPQA in quality assurance activities for HIV translational research and clinical trial networks.
- Cancer Prevention Clinical Trials Network Partner — Collaborates with CP-CTNet on early-phase clinical trials for cancer prevention agents.
- DataFax Partner — Uses DataFax as an electronic data capture system for clinical trial database management.
- ETOP-IBCSG Partner — Collaborates with ETOP-IBCSG on international clinical research in thoracic malignancies and breast cancer.
- Eunice Kennedy Shriver National Institute of Child Health and Human Development Government — Supporting funder of the IMPAACT Network.
- Harvard T.H. Chan School of Public Health Partner — Co-hosts the IMPAACT Statistical and Data Management Center with Frontier Science.
- Independent Data Monitoring Committees Partner — Provides independent statistical support and customized reporting to Independent Data Monitoring Committees for clinical trials.
- International Maternal Pediatric Adolescent AIDS Clinical Trials Network Partner — Provides research support for IMPAACT clinical trials focused on HIV in maternal, pediatric, and adolescent populations.
- Medidata Partner — Uses Medidata as an electronic data capture system for clinical trial database management.
- National Institute of Allergy and Infectious Diseases Government — Partnered with Frontier Science through its establishment of the AIDS Clinical Trials Group (ACTG), which Frontier Science supports with data management and analysis.
- National Institute of Allergy and Infectious Diseases Government — Primary funder of the IMPAACT Network.
- National Institute of Mental Health Government — Supporting funder of the IMPAACT Network.
- National Institutes of Health Government — Supports large-scale clinical trial networks that use Frontier Science's Stars enrollment system.
- OlympiA Partner — Provides research support for the OlympiA trial on adjuvant olaparib treatment in BRCA1/2 mutation carriers with high-risk breast cancer.
- OpenClinica Partner — Uses OpenClinica as an electronic data capture system for clinical trial database management.
- PHACS Partner — Frontier Science serves as the Data Management Center for the PHACS Network, supporting cohort research on pediatric HIV/AIDS.
- PROACTIVE Partner — Supports PROACTIVE NYS, a long-term follow-up study of infants who screen positive for congenital CMV in New York State.
- Pediatric HIV/AIDS Cohort Study Partner — Supports PHACS in investigating long-term effects of HIV and antiretroviral medications in children and young adults.
- Pharmaceutical Companies Partner — Provides data management and biostatistical services to pharmaceutical companies.
- REDCap Partner — Uses REDCap as an electronic data capture system for clinical trial database management.
- RePORT International Partner — Collaborates with RePORT International on research coordination for tuberculosis control and prevention.
- Research Networks Partner — Collaborates with research networks on clinical trials and observational studies.
- Specimen Repository Partner — Website designed, built, and hosted by Frontier Science to support specimen data management.
- Technical Writing department Partner — Collaborates with the Technical Writing department to produce tailored documentation, training materials, and full validation suites.
- Technical Writing department Partner — Internal department that supports the training team in creating study documentation.
- UPLIFT Partner — Supports UPLIFT (IMPAACT 2046), a study exploring breastfeeding practices among pregnant and postpartum women with HIV in the US.
+ 4 more
strategies · 4
How they approach the work
Named approaches extracted from this org’s sources. Where others share an approach, follow it to see the full set of orgs running it.
- Collaborative Clinical Research Modelmethodology: collaborative_clinical_researchBy partnering closely with investigators, sponsors, and research teams throughout the entire study lifecycle, Frontier Science ensures scientific rigor and high-quality data outcomes in clinical trials because sustained collaboration enhances protocol design, data integrity, and regulatory alignment.
- Risk-Based Monitoring with Tailored Quality Assurancemethodology: risk_based_monitoringBy prioritizing monitoring efforts on trial processes most critical to participant safety and data integrity, and by customizing audit teams and infrastructure to study-specific needs, Frontier Science improves trial quality, efficiency, and compliance because focused oversight reduces risk while optimizing resources.
- Statistical Innovation and Customizable Data Solutionsmethodology: statistical_innovationBy applying innovative statistical methodologies and developing customizable data management systems tailored to complex research challenges, Frontier Science enhances the validity and impact of clinical research because flexible, technically robust solutions improve data quality and analytical precision.
- Training and Support Grounded in Needs Assessment and Continuous Improvementmethodology: needs_based_trainingBy designing study-specific training based on collaborator needs and continuously evaluating its effectiveness, Frontier Science improves research team performance and data quality because aligned, adaptive education ensures consistent understanding and implementation of protocols.