irs program accomplishments · form 990 part iii · fy2024
What they reported doing
- #1 primary $3.12MNYSBC PROVIDES ACCESS TO HIGH-FIELD NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO FACULTY FROM ITS NINE MEMBER INSTITUTIONS. THE NMR FACILITY INSTRUMENTATION INCLUDES NINE NMR SPECTROMETERS THAT GENERALLY OPERATE 24 HRS/DAY, 7 DAYS/WEEK. IN 2024, EACH SPECTROMETER WAS AVAILABLE, ON AVERAGE, 345 DAYS. THESE RESOURCES ALLOW RESEARCHERS TO DETERMINE THE STRUCTURE OF PROTEINS IN SOLUTION AND IN SOLID STATE ATOMIC RESOLUTION, DATA THAT PROVIDES INSIGHT INTO THE FUNCTIONAL PROPERTIES OF THE PROTEINS. IN 2024, GROUP MEMBERS FROM THE LABORATORIES OF 17 AFFILIATED PRINCIPAL INVESTIGATORS MADE USE OF THESE INSTRUMENTS. DATA COLLECTED WITH THESE INSTRUMENTS PRODUCED 18 PUBLICATIONS IN EMINENT SCIENTIFIC JOURNALS. THE CENTER OPERATES THE CENTER ON MOLECULAR DYNAMICS BY COMD/NMR, A BIOMEDICAL TECHNOLOGY RESEARCH RESOURCE SUPPORTED BY U.S. NATIONAL INSTITUTES OF HEALTH GRANTS RM1 GM145397 AND LOCATED AT NYSBC. THE MISSION OF COMD-NMR IS TO MAKE AVAILABLE TO THE BIOLOGICAL RESEARCH COMMUNITY ADVANCED NMR SPECTROSCOPIC AND COMPUTATIONAL METHODS FOR CHARACTERIZING PROTEIN AND NUCLEIC ACID CONFORMATIONAL DYNAMICS IN BIOLOGICAL PROCESSES.
- #2 $1.43MNYSBC HAS MAINTAINED X-RAY CRYSTALLOGRAPHY RESOURCES AT BROOKHAVEN NATIONAL LABORATORY (BNL) SINCE 2003. NYSBC HAS DEVELOPED AND OPERATES BEAMLINE 19ID-NYX AT THE NATIONAL SYNCHROTRON LIGHT SOURCE II (NSLS-II). NYX PROVIDES THE NYSBC MEMBER INSTITUTIONS AND ASSOCIATED INVESTIGATORS WITH ACCESS TO SYNCHROTRON RADIATION AND INSTRUMENTATION NECESSARY FOR COLLECTING CRYSTALLOGRAPHIC DATA ON BIOLOGICAL MACROMOLECULES. NYX HAS PERFORMED TECHNICAL AND SCIENTIFIC COMMISSIONING AND STARTED USER OPERATIONS IN THE SPRING OF 2019. THE PRIMARY ACCOMPLISHMENTS OF THE BEAMLINE PROGRAM FOR 2024 WERE UPGRADES TO AUTOMATION AND SOFTWARE AND SUPPORTING USER EXPERIMENTS.
named programs · 6 · from sources
What they call their work
Beamline 19ID-NYX at NSLS-II
X-ray crystallography beamline at Brookhaven National Laboratory providing synchrotron radiation and instrumentation for collecting data on biological macromolecules; supports user experiments and technical development
Center on Molecular Dynamics by NMR (COMD-NMR)
NIH-funded Biomedical Technology Research Resource that develops and disseminates advanced NMR and computational methods for studying protein and nucleic acid dynamics in biological processes
Graduate Courses in Structural Biology
Offers accredited graduate-level courses in NMR spectroscopy, cryo-electron microscopy, and biomolecular NMR through member institutions including Columbia University and CUNY
NMR Spectroscopy Facility
Provides access to nine high-field NMR spectrometers operating 24/7 for determining protein structure and dynamics in solution and solid state; serves researchers from nine member institutions and supports publication of scientific findings
Short Training Courses
Provides hands-on training in NMR spectrometer operation, MicroED, and other structural biology techniques for researchers from member institutions
Simons Electron Microscopy Center (SEMC)
National cryo-EM facility funded by NIH and Simons Foundation; provides access to cutting-edge cryo-electron microscopy for solving structures of macromolecular assemblies
activities · 5 groups
What they do
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Biomedical Research and Innovation 2 activities
- Conducts structural biology research and technology developmentEngages in innovative research and technology development in structural biology, including method development for protein and nucleic acid dynamics using NMR, supported by NIH recognition for important technological contributions.
- Disseminates advanced structural biology methods and technologiesHosts the NIH National Center on Molecular Dynamics by NMR to disseminate NMR methodologies and makes cutting-edge structural biology techniques accessible to researchers at member institutions and nationally to advance biomedical research and human health.
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Research Facility Management 1 activity
- Hosts national cryoelectron microscopy facilityOperates one of three National Institutes of Health-funded national cryoelectron microscopy facilities, providing critical infrastructure and expertise for high-resolution structural analysis of biological macromolecules.
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Hands-On STEM Education Programs 1 activity
- Provides training and educational programs in structural biologyOffers accredited graduate courses, hands-on workshops, short courses (e.g., MicroED), and training sessions (e.g., Refeyn) for researchers and students; also conducts educational visits for K–12 students to promote science literacy.
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Open Research Infrastructure & Publishing 1 activity
- Supports affiliated principal investigators' researchProvides infrastructure and scientific support enabling research by affiliated principal investigators, resulting in multiple annual publications in high-impact journals across years 2020–2024.
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Uncategorized 4 activities
- Operates NYX beamline at NSLS-II synchrotronDesigned, built, and operates Beamline 19ID-NYX at Brookhaven National Laboratory’s National Synchrotron Light Source II, providing synchrotron radiation for X-ray crystallography to member institutions and associated researchers.
- Operates advanced structural biology facilitiesProvides access to and operates state-of-the-art structural biology technologies, including NMR spectroscopy with nine spectrometers available 345 days per year, cryo-electron microscopy, and X-ray beamline facilities such as Beamline 19ID-NYX at NSLS-II for crystallographic data collection on biological macromolecules.
- Provides gene-to-structure protein research pipelineOffers a full-service pipeline for protein research from target selection through structure determination, including cloning, expression, purification, crystallization, and structure analysis, available to academic and for-profit scientists with a focus on membrane proteins and difficult targets.
- Upgrades and maintains beamline automation and software systemsContinuously improves beamline capabilities by upgrading automation and software systems for Beamline 19ID-NYX, supporting enhanced user experiments in 2023 and 2024.
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financials · form 990 · fy2024
revenue
Total revenue$19.95M
Contributions & grants$18.63M93%
Program service revenue$00%
Investment income$688K3%
Other revenue$631K
expenses
Total expenses$28.45M
Program expenses84%
Admin / overhead16%
Fundraising0%
Salaries & benefits$12.80M
Grants paid out$170K
Largest expense lineCompensation
balance sheet
Total assets$133.94M
Cash$1.59M
Investments$15.24M
Liabilities$11.19M
Net assets$122.75M
Liquid reserves7.1 mo
3 years on record · 2020–2024 · YoY revenue -47.1%
leadership · form 990 part vii · fy2024
Who runs it
paid leadership · 6
| Name | Title | Hours/wk | Compensation |
|---|---|---|---|
| DR JEFFREY KIEFT | EXECUTIVE DIRECTOR | 40 | $686K |
| DR ALEX DE MARCO | SEMC DIRECTOR | 40 | $477K |
| MR ARJUN KOSHAL | MANAGING DIRECTOR | 40 | $406K |
| MS DEBBIE TRIFILIO | DIRECTOR OF FINANCE AND OPERATIONS | 40 | $324K |
| DR KEVIN BATTAILE | NYS BEAMLINE DIRECTOR/LEAD SCIENTIST | 40 | $302K |
| DR MICHAEL GOGER | SENIOR SCIENTIST & NMR MANAGER | 40 | $242K |
board members · 17
- DR ANEEL AGGARWAL — BOARD MEMBER
- DR ANN MCDERMOTT — BOARD MEMBER
- DR CHRISTOPHER LIMA — BOARD MEMBER
- DR CRINA NIMIGEAN — BOARD MEMBER
- DR DAVID COWBURN — BOARD MEMBER
- DR DAVID HIRSH — BOARD MEMBER
- DR FREDERICK MAXFIELD — SECRETARY
- DR KEVIN GARDNER — CHAIRMAN
- DR MING-MING ZHOU — BOARD MEMBER
- DR NINA GRAY — BOARD MEMBER
- DR PILAR COSSIO — BOARD MEMBER
- DR RAJENDRA K AGRAWAL — BOARD MEMBER
- DR SETH DARST — BOARD MEMBER
- DR STEPHEN LONG — BOARD MEMBER
- DR STEVEN C ALMO — BOARD MEMBER
- DR TIMOTHY P O'CONNOR — TREASURER
- DR TONY M LISS — BOARD MEMBER
relationships · 34
Who they work with
- Albert Einstein College of Medicine of Yeshiva University Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
- BROOKHAVEN NATIONAL LABORATORY Partner — Hosts NYSBC's X-ray crystallography resources and Beamline 19ID-NYX at the National Synchrotron Light Source II.
- Brookhaven National Laboratory Partner — Collaborates with Brookhaven National Laboratory to operate beamline NYX at its NSLS-II synchrotron facility.
- Brookhaven National Laboratory Partner — Hosts the NYSBC X-ray crystallographic facility at the National Synchrotron Light Source II.
- CENTER ON MEMBRANE PROTEIN PRODUCTION AND ANALYSIS Partner — Collaborative center established with NYSBC to develop technologies for production and study of membrane proteins; jointly received NIH P41 grant.
- City College of New York Partner — Hosts the NYSBC main facility at 89 Convent Avenue on its campus.
- City University Of New York Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
- Columbia University Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
- Harvard Medical School Partner — Collaborates with Dr. Stephen Harrison, Professor and Director of the Center for Molecular and Cellular Dynamics
- Helmholtz Munich Partner — Collaborates with Dr. Michael Sattler, Professor
- Icahn School of Medicine at Mount Sinai Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
- Johns Hopkins University School of Medicine Partner — Collaborates with Dr. Rachel Green, Professor of Molecular Biology and Genetics
- MRC Laboratory of Molecular Biology, University of Cambridge Partner — Collaborates with Dr. Venkatraman Ramakrishnan and Dr. Richard Henderson, Group Leaders
- Memorial Sloan Kettering Cancer Center Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
- NATIONAL INSTITUTES OF HEALTH Government — Funds the Center on Molecular Dynamics by COMD/NMR through grants RM1 GM145397 and previously P41 GM118302.
- NCCAT Partner — Co-hosts the MicroED Short Course with NYSBC and SEMC.
- NIH Funder — Provides center grants that support NYSBC's research, training, and innovation activities.
- NIH National Center on Molecular Dynamics by NMR Government — Houses and operates the NIH-funded national center focused on NMR methodologies.
- National Institutes of Health Government — Funds NYSBC's cryoelectron microscopy group as one of three national facilities and recognizes the organization for technology development.
- National Institutes of Health Government — Funds the NYSBC's Cryoelectron microscopy group and recognizes the institution for technology development.
- National Institutes of Health Partner — Collaborates with Dr. Adriaan Bax, Chief of Biophysical NMR Spectroscopy Section
- National Synchrotron Light Source II Partner — Collaborates on operation of the NYX facility for structural biology research.
- New York Genome Center Partner — Collaborates with Dr. Harold Varmus, Senior Associate Core Member
- New York University Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
- SEMC Partner — Co-hosts the MicroED Short Course with NYSBC and NCCAT.
- Simons Electron Microscopy Center Partner — Collaborates with the Simons Electron Microscopy Center for cryoEM structure determination.
- Simons Foundation Funder — Provides generous grants supporting NYSBC's operations as a “Center of Centers”.
- Simons Foundation Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
- Technical University of Munich Partner — Collaborates with Dr. Michael Sattler, Professor
- The Rockefeller University Partner — Represented on the Board of Directors of NEW YORK STRUCTURAL BIOLOGY CENTER INC
+ 4 more
strategies · 5
How they approach the work
Named approaches extracted from this org’s sources. Where others share an approach, follow it to see the full set of orgs running it.
- Consortium-Based Access Modelmethodology: consortium_modelBy organizing access to advanced structural biology instrumentation through a collaborative consortium, the organization enables research that would be infeasible for individual institutions due to cost or complexity, because shared infrastructure lowers barriers and promotes equitable use of high-end technologies.
- Gene-to-Structure Pipelinemethodology: gene-to-structure_pipelineBy implementing an integrated pipeline from gene selection to structure determination, the organization accelerates protein research, because end-to-end integration reduces bottlenecks and increases efficiency in structural biology workflows.
- Integrated Expertise and Technology Modelmethodology: integrated_structural_biologyBy combining cutting-edge instrumentation with expert-supported training and consultation, the organization enhances research outcomes, because integrated access to tools and knowledge enables more effective and innovative structural biology projects than technology alone would allow.
- Integrative Structural Biology Approachmethodology: integrative_structural_biologyBy combining computational methods with experimental structural biology techniques, the organization models macromolecular systems in biologically relevant contexts, because integration across disciplines produces more physiologically accurate insights than isolated methods.
- Open-Access Technology Disseminationmethodology: open-access technology resourceBy making advanced NMR and computational methods openly available to the broader research community, the organization advances biological research, because open access to specialized technologies enables wider scientific innovation and collaboration.